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TitleA strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.
Journal, issue, pagesCell Rep Med, Vol. 6, Page 101985-101985, Year 2025
Publish dateApr 25, 2024 (structure data deposition date)
AuthorsPatel, P.N. / Diouf, A. / Dickey, T.H. / Tang, W.K. / Hopp, C.S. / Traore, B. / Long, C.A. / Miura, K. / Crompton, P.D. / Tolia, N.H.
External linksCell Rep Med / PubMed:40020675
MethodsX-ray diffraction
Resolution2.8 - 2.9 Å
Structure data

PDB-9bjg:
Crystal structure of broadly neutralizing human monoclonal antibody 75B10 in complex with AMA1
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-9bjh:
Crystal structure of neutralizing human monoclonal antibody 75C8 in complex with AMA1 DI-DII
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum 3d7 (eukaryote)
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Apical membrane antigen 1 / Plasmodium / Malaria / Antigen-Antibody complex / AMA1

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