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Structure paper

TitleIntegrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Journal, issue, pagesNat Commun, Vol. 15, Page 10037-10037, Year 2024
Publish dateSep 21, 2023 (structure data deposition date)
AuthorsSharp, S.Y. / Martella, M. / D'Agostino, S. / Milton, C.I. / Ward, G. / Woodhead, A.J. / Richardson, C.J. / Carr, M.G. / Chiarparin, E. / Cons, B.D. ...Sharp, S.Y. / Martella, M. / D'Agostino, S. / Milton, C.I. / Ward, G. / Woodhead, A.J. / Richardson, C.J. / Carr, M.G. / Chiarparin, E. / Cons, B.D. / Coyle, J. / East, C.E. / Hiscock, S.D. / Martinez-Fleites, C. / Mortenson, P.N. / Palmer, N. / Pathuri, P. / Powers, M.V. / Saalau, S.M. / St Denis, J.D. / Swabey, K. / Vinkovic, M. / Walton, H. / Williams, G. / Clarke, P.A.
External linksNat Commun / PubMed:40016190
MethodsX-ray diffraction
Resolution1.585 - 2.191 Å
Structure data

PDB-8qm4:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 1.849 Å

PDB-8qm5:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 1.889 Å

PDB-8qm6:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-8qm7:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 2.191 Å

PDB-8qm8:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 1.585 Å

PDB-8qm9:
Potential drug binding sites for translation initiation factor eIF4E
Method: X-RAY DIFFRACTION / Resolution: 1.973 Å

Chemicals

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL


ChemComp, No image

ChemComp-W5B:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-W4U:
Unknown entry


ChemComp, No image

ChemComp-W2N:
Unknown entry


ChemComp, No image

ChemComp-W4B:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER


ChemComp, No image

ChemComp-W5K:
Unknown entry


ChemComp, No image

ChemComp-W4K:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsTRANSLATION / translation initiation factor / translation regulator / protein biosynthesis / RNA binding

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