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TitleDesign of high-affinity binders to immune modulating receptors for cancer immunotherapy.
Journal, issue, pagesNat Commun, Vol. 16, Page 2001-2001, Year 2025
Publish dateFeb 9, 2023 (structure data deposition date)
AuthorsYang, W. / Hicks, D.R. / Ghosh, A. / Schwartze, T.A. / Conventry, B. / Goreshnik, I. / Allen, A. / Halabiya, S.F. / Kim, C.J. / Hinck, C.S. ...Yang, W. / Hicks, D.R. / Ghosh, A. / Schwartze, T.A. / Conventry, B. / Goreshnik, I. / Allen, A. / Halabiya, S.F. / Kim, C.J. / Hinck, C.S. / Lee, D.S. / Bera, A.K. / Li, Z. / Wang, Y. / Schlichthaerle, T. / Cao, L. / Huang, B. / Garrett, S. / Gerben, S.R. / Rettie, S. / Heine, P. / Murray, A. / Edman, N. / Carter, L. / Stewart, L. / Almo, S.C. / Hinck, A.P. / Baker, D.
External linksNat Commun / PubMed:40011465
MethodsX-ray diffraction
Resolution1.24 Å
Structure data

PDB-8g4k:
Complex of TbRII mini protein binder bound to the TbRII ECD
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / TbRII / TGF-b type II receptor / Computationally designed mini protein binder / MPB

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