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Structure paper

TitleStructural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.
Journal, issue, pagesAcs Omega, Vol. 10, Page 5795-5808, Year 2025
Publish dateOct 1, 2024 (structure data deposition date)
AuthorsConley, J.F. / Brown, L.E. / McNeely, J.H. / Pelletier, J. / Porco Jr., J.A. / Allen, K.N.
External linksAcs Omega / PubMed:39989799
MethodsX-ray diffraction
Resolution1.69 Å
Structure data

PDB-9dts:
Crystal structure of the human eIF4A1/AMPPNP/amidino-rocaglate/polypurine RNA complex
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

PDB-1bb1:
CRYSTAL STRUCTURE OF A DESIGNED, THERMOSTABLE HETEROTRIMERIC COILED COIL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSLATION / HYDROLASE/RNA / RNA helicase / DEAD box helicase / rocaglate / protein-RNA complex / HYDROLASE-RNA complex

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