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TitleA first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy.
Journal, issue, pagesSignal Transduct Target Ther, Vol. 10, Page 70-70, Year 2025
Publish dateJan 21, 2025 (structure data deposition date)
AuthorsXiao, H. / Wang, A. / Shuai, W. / Qian, Y. / Wu, C. / Wang, X. / Yang, P. / Sun, Q. / Wang, G. / Ouyang, L.
External linksSignal Transduct Target Ther / PubMed:39979271
MethodsX-ray diffraction
Resolution2.1 - 2.33 Å
Structure data

PDB-9lnr:
Crystal structure of SKLB-D18 with ERK2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-9lta:
Crystal Structure of Compound SKLB-D18 with MAPK7 (ERK5)
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

PDB-1ekr:
MOAC PROTEIN FROM E. COLI

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / ERK2 / inhibitor / cancer / SIGNALING PROTEIN / ERK5

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