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TitleNipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties.
Journal, issue, pagesMabs, Vol. 17, Page 2461191-2461191, Year 2025
Publish dateDec 12, 2024 (structure data deposition date)
AuthorsSeth, N.P. / Xu, R. / DuPrie, M. / Choudhury, A. / Sihapong, S. / Tyler, S. / Meador, J. / Avery, W. / Cochran, E. / Daly, T. ...Seth, N.P. / Xu, R. / DuPrie, M. / Choudhury, A. / Sihapong, S. / Tyler, S. / Meador, J. / Avery, W. / Cochran, E. / Daly, T. / Brown, J. / Rutitzky, L. / Markowitz, L. / Kumar, S. / Beavers, T. / Bhattacharya, S. / Chen, H. / Parge, V. / Price, K. / Wang, Y. / Sukumaran, S. / Pao, Y. / Abouzahr, K. / Elwood, F. / Duffner, J. / Roy, S. / Narayanaswami, P. / Hubbard, J.J. / Ling, L.E.
External linksMabs / PubMed:39936406
MethodsX-ray diffraction
Resolution2.41 Å
Structure data

PDB-9mi6:
Crystal structure of human FcRn in complex with nipocalimab Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / NEONATAL FC RECEPTOR / FCRN / INHIBITOR / BETA 2 MICROGLOBULIN / B2M / COMPLEX(ANTIBODY-ANTIGEN)

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