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TitleCharacterization of a C-methyltransferase from Streptomyces griseoviridis - crystal structure, mechanism, and substrate scope.
Journal, issue, pagesChem Sci, Vol. 16, Page 4519-4527, Year 2025
Publish dateAug 5, 2024 (structure data deposition date)
AuthorsHaase, M. / Weiergraber, O.H. / David, B. / Pfirmann, E.L. / Paschold, B. / Gohlke, H. / Pietruszka, J.
External linksChem Sci / PubMed:39926702
MethodsX-ray diffraction
Resolution1.47 Å
Structure data

PDB-9gdj:
C-Methyltransferase SgMT from Streptomyces griseoviridis
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

Chemicals

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • streptomyces griseoviridis (bacteria)
KeywordsTRANSFERASE / methyl transfer / pyrroloindole synthesis / Rossmann fold / S-adenosyl methionine

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