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Structure paper

TitleBiparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity.
Journal, issue, pagesMabs, Vol. 17, Page 2457471-2457471, Year 2025
Publish dateSep 6, 2024 (structure data deposition date)
AuthorsLoyau, J. / Monney, T. / Montefiori, M. / Bokhovchuk, F. / Streuli, J. / Blackburn, M. / Goepfert, A. / Caro, L.N. / Chakraborti, S. / De Angelis, S. ...Loyau, J. / Monney, T. / Montefiori, M. / Bokhovchuk, F. / Streuli, J. / Blackburn, M. / Goepfert, A. / Caro, L.N. / Chakraborti, S. / De Angelis, S. / Grandclement, C. / Blein, S. / Mbow, M.L. / Srivastava, A. / Perro, M. / Sammicheli, S. / Zhukovsky, E.A. / Dyson, M. / Dreyfus, C.
External linksMabs / PubMed:39882744
MethodsX-ray diffraction
Resolution1.84 - 2.7 Å
Structure data

PDB-9gox:
Crystal structure of Fab B6-D9 in complex with CD38
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

PDB-9goy:
Crystal structure of Fab E2-RecA in complex with CD38
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / Biparatopic bispecific antibody / antibody / Innate cell modulator / CD38

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