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Structure paper

TitleCharacterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach.
Journal, issue, pagesBiochem. J., Vol. 482, Year 2025
Publish dateAug 11, 2023 (structure data deposition date)
AuthorsPearson, L.A. / Petit, A.P. / Mendoza Martinez, C. / Bellany, F. / Lin, D. / Niven, S. / Swift, R. / Eadsforth, T. / Fyfe, P. / Paul, M. ...Pearson, L.A. / Petit, A.P. / Mendoza Martinez, C. / Bellany, F. / Lin, D. / Niven, S. / Swift, R. / Eadsforth, T. / Fyfe, P. / Paul, M. / Postis, V. / Hu, X. / Cowling, V.H. / Gray, D.W.
External linksBiochem. J. / PubMed:39869500
MethodsX-ray diffraction
Resolution1.96 - 2.5 Å
Structure data

PDB-8q69:
Crystal structure of HsRNMT complexed with inhibitor DDD1060606
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-8q8g:
Crystal structure of HsRNMT complexed with inhibitor DDD1870799
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8q9w:
Crystal structure of HsRNMT complexed with sinefungin and GMP-PnP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE


ChemComp, No image

ChemComp-K7R:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-O94:
Unknown entry

ChemComp-SFG:
SINEFUNGIN

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / Methyl transferase

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