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TitleEvaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel cereblon E3 ligase modulators in myeloma.
Journal, issue, pagesBlood, Vol. 145, Page 2630-2644, Year 2025
Publish dateMay 31, 2024 (structure data deposition date)
AuthorsChrisochoidou, Y. / Scarpino, A. / Morales, S. / Martin, S. / Bird, S. / Li, Y. / Walker, B. / Caldwell, J. / Le Bihan, Y.V. / Pawlyn, C.
External linksBlood / PubMed:39841463
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-9fjx:
Crystal structure of human CRBN-DDB1 in complex with Lenalidomide
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-ZN:
Unknown entry

ChemComp-LVY:
S-Lenalidomide

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / E3-ligase / Degradation / Glue / Protac

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