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TitleA widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
Journal, issue, pagesBiorxiv, Year 2024
Publish dateOct 25, 2024 (structure data deposition date)
AuthorsChang, R.B. / Toyoda, H.C. / Hobbs, S.J. / Richmond-Buccola, D. / Wein, T. / Burger, N. / Chouchani, E.T. / Sorek, R. / Kranzusch, P.J.
External linksBiorxiv / PubMed:39803557
MethodsX-ray diffraction
Resolution2.08 Å
Structure data

PDB-9e4w:
Structure of Bacillus phage SPO1 anti-CBASS 4 (Acb4) in complex with 3'3'-cGAMP
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

ChemComp-4BW:
2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one

ChemComp-HOH:
WATER

Source
  • bacillus phage spo1 (virus)
KeywordsVIRAL PROTEIN / anti-cbass / immune evasion / viral sponge

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