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Structure paper

TitleIsolation and structure of broad SIV-neutralizing antibodies reveal a proximal helical MPER epitope recognized by a rhesus multi-donor class.
Journal, issue, pagesCell Rep, Vol. 44, Page 115163-115163, Year 2025
Publish dateMay 2, 2024 (structure data deposition date)
AuthorsGorman, J. / Du, R. / Lai, Y.T. / Ahmadi, M.S. / King, H.A.D. / Song, K. / Manalang, K. / Gonelli, C.A. / Schramm, C.A. / Cheng, C. ...Gorman, J. / Du, R. / Lai, Y.T. / Ahmadi, M.S. / King, H.A.D. / Song, K. / Manalang, K. / Gonelli, C.A. / Schramm, C.A. / Cheng, C. / Nguyen, R. / Ambrozak, D. / Druz, A. / Shen, C.H. / Yang, Y. / Douek, D.C. / Kwong, P.D. / Roederer, M. / Mason, R.D.
External linksCell Rep / PubMed:39792559
MethodsX-ray diffraction
Resolution1.96 - 3.58 Å
Structure data

PDB-9blx:
Rhesus macaque ITS111.01 Fab in complex with SIV MPER peptide
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-9bns:
Rhesus macaque ITS114.01 Fab in complex with SIV MPER peptide
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9bp1:
Rhesus macaque ITS110.01 Fab in complex with SIV Env MPER peptide
Method: X-RAY DIFFRACTION / Resolution: 3.58 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • macaca mulatta (Rhesus monkey)
  • simian immunodeficiency virus
KeywordsIMMUNE SYSTEM/Viral Protein / Fab / MPER / membrane-proximal external region / HIV-1 / gp41 / IMMUNE SYSTEM / SIV / IMMUNE SYSTEM-Viral Protein complex / antibody

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