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TitleMultiple myeloma-associated non-crystalline proximal tubulopathy and crystalline cast nephropathy: Biochemical and structural features of disease-causing monoclonal kappa light chains.
Journal, issue, pagesFaseb J., Vol. 39, Page e70296-e70296, Year 2025
Publish dateJan 17, 2024 (structure data deposition date)
AuthorsEzawa, T. / Otomo, R. / Kariya, Y. / Nozawa, K. / Kyoya, S. / Furutani, C. / Noguchi, K. / Yohda, M. / Odaka, M. / Matsumura, H. ...Ezawa, T. / Otomo, R. / Kariya, Y. / Nozawa, K. / Kyoya, S. / Furutani, C. / Noguchi, K. / Yohda, M. / Odaka, M. / Matsumura, H. / Saito, A. / Saito, M. / Abe, F. / Fujioka, Y. / Kitadate, A. / Wakui, H. / Takahashi, N.
External linksFaseb J. / PubMed:39781602
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-8xwz:
Non-crystalline proximal tubulopathy and crystalline cast nephropathy-causing Bence-Jones protein PT-CN: An entire immunoglobulin kappa light chain dimer
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ETX:
2-ETHOXYETHANOL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Bence-Jones protein / immunoglobulin / kappa light chain

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