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TitleCell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Non-Kinases and Kinases.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 64, Page e202422372-e202422372, Year 2025
Publish dateNov 4, 2024 (structure data deposition date)
AuthorsChen, P. / Wang, L. / Wang, X. / Sun, J. / Miao, F. / Wang, Z. / Yang, F. / Xiang, M. / Gu, M. / Li, S. ...Chen, P. / Wang, L. / Wang, X. / Sun, J. / Miao, F. / Wang, Z. / Yang, F. / Xiang, M. / Gu, M. / Li, S. / Zhang, J. / Yuan, P. / Lu, X. / Zhang, Z.M. / Gao, L. / Yao, S.Q.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:39778034
MethodsX-ray diffraction
Resolution2.50011813338 Å
Structure data

PDB-9kds:
The crystal structure of human AURKA kinase domain in complex with RA1
Method: X-RAY DIFFRACTION / Resolution: 2.50011813338 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / Inhibitor

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