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TitlepH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma.
Journal, issue, pagesAcs Nano, Vol. 19, Page 307-321, Year 2025
Publish dateApr 22, 2024 (structure data deposition date)
AuthorsMeng, J.L. / Dong, Z.X. / Chen, Y.R. / Lin, M.H. / Liu, Y.C. / Roffler, S.R. / Lin, W.W. / Chang, C.Y. / Tzou, S.C. / Cheng, T.L. ...Meng, J.L. / Dong, Z.X. / Chen, Y.R. / Lin, M.H. / Liu, Y.C. / Roffler, S.R. / Lin, W.W. / Chang, C.Y. / Tzou, S.C. / Cheng, T.L. / Huang, H.C. / Li, Z.Q. / Lin, Y.C. / Su, Y.C.
External linksAcs Nano / PubMed:39749925
MethodsX-ray diffraction
Resolution2.26 Å
Structure data

PDB-8z95:
Humanized anti-PEG h6.3 Fab in complex with PEG
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-PEU:
2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL / precipitant*YM

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Anti-PEG / Fab

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