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TitleTrojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2319483121-e2319483121, Year 2025
Publish dateMar 11, 2022 (structure data deposition date)
AuthorsLuo, S. / Li, X.R. / Gong, X.T. / Kulikovsky, A. / Qu, F. / Beis, K. / Severinov, K. / Dubiley, S. / Feng, X. / Dong, S.H. / Nair, S.K.
External linksProc. Natl. Acad. Sci. USA / PubMed:39739799
MethodsX-ray diffraction
Resolution1.65 - 2 Å
Structure data

PDB-7z6f:
Crystal structure of the substrate-binding protein YejA in complex with peptide fragment
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8fsq:
Complex Structure of YejA with Microcin C7
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-8fsr:
Complex Structure of YejA with fMccA
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-8fss:
Complex Structure of YejA-S481A with Microcin C7
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsTRANSPORT PROTEIN / ABC importer / peptide transporter / substrate-binding protein / PEPTIDE BINDING PROTEIN/ANTIBIOTIC / Trojan Horse / Microcin / ANTIBIOTIC / PEPTIDE BINDING PROTEIN-ANTIBIOTIC complex / TRANSPORT PROTEIN/ANTIBIOTIC / TRANSPORT PROTEIN-ANTIBIOTIC complex

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