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TitleCDK2-based CDK7 mimic as a tool for structural analysis: Biochemical validation and crystal structure with SY5609.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 294, Page 139117-139117, Year 2025
Publish dateAug 27, 2024 (structure data deposition date)
AuthorsSkerlova, J. / Krejcirikova, V. / Perina, M. / Vojackova, V. / Fabry, M. / Krystof, V. / Jorda, R. / Rezacova, P.
External linksInt. J. Biol. Macromol. / PubMed:39733900
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-9gla:
Crystal structure of a CDK2-based CDK7 mimic with inhibitor SY5609
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals


ChemComp, No image

ChemComp-YNK:
Unknown entry

ChemComp-SGM:
MONOTHIOGLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / cyclin-dependent kinase / inhibitor / SY5609 / selectivity / structure-assisted inhibitor design

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