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TitleDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase.
Journal, issue, pagesNat Commun, Vol. 15, Page 10724-10724, Year 2024
Publish dateApr 14, 2024 (structure data deposition date)
AuthorsSchmidt, N. / Kumar, A. / Korf, L. / Dinh-Fricke, A.V. / Abendroth, F. / Koide, A. / Linne, U. / Rakwalska-Bange, M. / Koide, S. / Essen, L.O. ...Schmidt, N. / Kumar, A. / Korf, L. / Dinh-Fricke, A.V. / Abendroth, F. / Koide, A. / Linne, U. / Rakwalska-Bange, M. / Koide, S. / Essen, L.O. / Vazquez, O. / Hantschel, O.
External linksNat Commun / PubMed:39715735
MethodsX-ray diffraction
Resolution2.73 - 2.91 Å
Structure data

PDB-9f00:
Complex between D-SH2 domain of ABL with monobody DAM27
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

PDB-9f01:
Complex between D-SH2 domain of ABL with monobody 'DAM21
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • synthetic construct (others)
KeywordsPROTEIN BINDING / Complex / monobody / SH2 domain / mirror-image phage display / D-protein / nanobody

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