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TitleThe carbonyl nucleobase adduct M 3 Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells.
Journal, issue, pagesImmunity, Year 2024
Publish dateNov 16, 2022 (structure data deposition date)
AuthorsChancellor, A. / Constantin, D. / Berloffa, G. / Yang, Q. / Nosi, V. / Loureiro, J.P. / Colombo, R. / Jakob, R.P. / Joss, D. / Pfeffer, M. ...Chancellor, A. / Constantin, D. / Berloffa, G. / Yang, Q. / Nosi, V. / Loureiro, J.P. / Colombo, R. / Jakob, R.P. / Joss, D. / Pfeffer, M. / De Simone, G. / Morabito, A. / Schaefer, V. / Vacchini, A. / Brunelli, L. / Montagna, D. / Heim, M. / Zippelius, A. / Davoli, E. / Haussinger, D. / Maier, T. / Mori, L. / De Libero, G.
External linksImmunity / PubMed:39701104
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-8bp6:
Structure of MHC-class I related molecule MR1 with bound M3Ade.
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-R8F:
(1R,5S)-8-(9H-purin-6-yl)-2-oxa-8-azabicyclo[3.3.1]nona-3,6-diene-4,6-dicarbaldehyde

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Major histocompatibility complex class I-related gene protein / antigen / immnun system

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