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Structure paper

TitleBiocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2.
Journal, issue, pagesChem Sci, Vol. 16, Page 1302-1307, Year 2025
Publish dateAug 30, 2024 (structure data deposition date)
AuthorsSalihovic, A. / Ascham, A. / Rosenqvist, P.S. / Taladriz-Sender, A. / Hoskisson, P.A. / Hodgson, D.R.W. / Grogan, G. / Burley, G.A.
External linksChem Sci / PubMed:39691463
MethodsX-ray diffraction
Resolution2.41 - 2.48 Å
Structure data

PDB-9gn2:
Nucleoside-2'-deoxyribosyltransferase from Lactobacillus leichmannii. Complex with ribose and cytosine
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

PDB-9gn4:
Nucleoside-2'-deoxyribosyltransferase from Lactobacillus leichmannii. Y7F/D72N mutant with cytidine
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

Chemicals

ChemComp-CYT:
6-AMINOPYRIMIDIN-2(1H)-ONE

ChemComp-RIB:
alpha-D-ribofuranose

ChemComp-HOH:
WATER

ChemComp-CTN:
4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE

Source
  • lactobacillus leichmannii (bacteria)
KeywordsTRANSFERASE / Nucleoside-2'-deoxyribosyltransferase

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