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Structure paper

TitleThe Structural and Dynamic Insights into the Ala97Ser Amyloidogenic Mutation in Transthyretin.
Journal, issue, pagesChem Asian J, Page e202401438-e202401438, Year 2024
Publish dateJan 10, 2023 (structure data deposition date)
AuthorsFeng, Y.C. / Agrawal, S. / Yang, C.H. / Chang, H.C. / Kuo, L. / Yu, W.C. / Liu, Y.T. / Yu, T.Y.
External linksChem Asian J / PubMed:39668552
MethodsX-ray diffraction
Resolution1.8 - 1.88 Å
Structure data

PDB-8i00:
Crystal structure of A97S transthyretin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8i0o:
Crystal structure of Transthyretin variant A97S in monomeric form
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Amyloid / Transporter / Serum protein / Tetramer / STRUCTURAL PROTEIN / monomeric form / ATTR

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