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TitleIntestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor.
Journal, issue, pagesNat. Biotechnol., Vol. 43, Page 1772-1777, Year 2025
Publish dateJan 23, 2024 (structure data deposition date)
AuthorsFu, Y. / Ding, X. / Zhang, M. / Feng, C. / Yan, Z. / Wang, F. / Xu, J. / Lin, X. / Wang, L. / Fan, Y. ...Fu, Y. / Ding, X. / Zhang, M. / Feng, C. / Yan, Z. / Wang, F. / Xu, J. / Lin, X. / Wang, L. / Fan, Y. / Li, T. / Yin, Y. / Liang, X. / Xu, C. / Chen, S. / Pulous, F.E. / Gennert, D. / Pun, F.W. / Kamya, P. / Ren, F. / Aliper, A. / Zhavoronkov, A.
External linksNat. Biotechnol. / PubMed:39663371
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-8y0v:
HIF prolyl hydroxylase 2 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

PDB-1d5x:
X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Inhibitor

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