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-Structure paper
| Title | A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. |
|---|---|
| Journal, issue, pages | Plos Pathog., Vol. 20, Page e1012429-e1012429, Year 2024 |
| Publish date | Jul 11, 2024 (structure data deposition date) |
 Authors | Xie, S.C. / Tai, C.W. / Morton, C.J. / Ma, L. / Huang, S.C. / Wittlin, S. / Du, Y. / Hu, Y. / Dogovski, C. / Salimimarand, M. ...Xie, S.C. / Tai, C.W. / Morton, C.J. / Ma, L. / Huang, S.C. / Wittlin, S. / Du, Y. / Hu, Y. / Dogovski, C. / Salimimarand, M. / Griffin, R. / England, D. / de la Cruz, E. / Deni, I. / Yeo, T. / Burkhard, A.Y. / Striepen, J. / Schindler, K.A. / Crespo, B. / Gamo, F.J. / Khandokar, Y. / Hutton, C.A. / Rabie, T. / Birkholtz, L.M. / Famodimu, M.T. / Delves, M.J. / Bolsher, J. / Koolen, K.M.J. / van der Laak, R. / Aguiar, A.C.C. / Pereira, D.B. / Guido, R.V.C. / Creek, D.J. / Fidock, D.A. / Dick, L.R. / Brand, S.L. / Gould, A.E. / Langston, S. / Griffin, M.D.W. / Tilley, L. |
 External links | Plos Pathog. / PubMed:39652589 |
| Methods | X-ray diffraction |
| Resolution | 1.8 Å |
| Structure data |  PDB-9cll: |
| Chemicals |  PDB-1azg:  ChemComp-MLI:  ChemComp-CL:  ChemComp-NA:  ChemComp-HOH: |
| Source |
|
 Keywords | LIGASE/INHIBITOR / Inhibitor complex / LIGASE / LIGASE-INHIBITOR complex |
plasmodium falciparum 3d7 (eukaryote)