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Structure paper

TitleInsights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Journal, issue, pagesCell Chem Biol, Vol. 31, Page 2096-2111.e7, Year 2024
Publish dateAug 1, 2023 (structure data deposition date)
AuthorsTemme, J.S. / Tan, Z. / Li, M. / Yang, M. / Wlodawer, A. / Huang, X. / Schneekloth Jr., J.S. / Gildersleeve, J.C.
External linksCell Chem Biol / PubMed:39637855
MethodsX-ray diffraction
Resolution1.4 - 1.76 Å
Structure data

PDB-8tn4:
The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, used to study poly-N-acetyl-glucosamine broadly expressed in biofilm-forming pathogenclonal antibody
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8tn5:
The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a GlcNH2
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-8tn7:
The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a disaccharide
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-GCS:
2-amino-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / monoclonal antibody / TG10 / PANG / GlcNac / GlcNac-GlcNac

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