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Structure paper

TitleAllosteric substrate release by a sialic acid TRAP transporter substrate binding protein.
Journal, issue, pagesCommun Biol, Vol. 7, Page 1559-1559, Year 2024
Publish dateJun 26, 2024 (structure data deposition date)
AuthorsSchneberger, N. / Hendricks, P. / Peter, M.F. / Gehrke, E. / Binder, S.C. / Koenig, P.A. / Menzel, S. / Thomas, G.H. / Hagelueken, G.
External linksCommun Biol / PubMed:39580575
MethodsX-ray diffraction
Resolution2.05 - 2.81 Å
Structure data

PDB-9fvb:
Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#2)
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-9fvc:
Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#1)
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

PDB-9fve:
Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2)
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-IMD:
IMIDAZOLE

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-SLB:
N-acetyl-beta-neuraminic acid

Source
  • vibrio cholerae (bacteria)
  • vicugna pacos (alpaca)
KeywordsTRANSPORT PROTEIN / Substrate binding protein / TRAP transporter / VHH antibody / Nanobody / Complex / sialic acid

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