EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
ジャーナル・号・ページ	Nat Commun, Vol. 15, Issue 1, Page 10012, Year 2024
掲載日	2024年11月19日
著者	Ju Sun / Tianyi Zheng / Mingjun Jia / Yanjun Wang / Jingru Yang / Yun Liu / Pengyun Yang / Yufeng Xie / Honglei Sun / Qi Tong / Jiaming Li / Jing Yang / Guanghua Fu / Yi Shi / Jianxun Qi / Wenjun Liu / Jinhua Liu / Wen-Xia Tian / George F Gao / Yuhai Bi /
PubMed 要旨	The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the ...The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype.
リンク	Nat Commun / PubMed:39562538 / PubMed Central
手法	EM (単粒子)
解像度	2.31 - 2.87 Å
構造データ	38311 8xg1 EMDB-38311, PDB-8xg1: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.53 Å 38348 8xhe EMDB-38348, PDB-8xhe: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.64 Å 38349 8xhf EMDB-38349, PDB-8xhf: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.39 Å 38350 8xhg EMDB-38350, PDB-8xhg: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.54 Å 38351 8xhh EMDB-38351, PDB-8xhh: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.38 Å 38597 8xr7 EMDB-38597, PDB-8xr7: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.62 Å 38598 8xr8 EMDB-38598, PDB-8xr8: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.53 Å 38599 8xr9 EMDB-38599, PDB-8xr9: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.6 Å 38600 8xra EMDB-38600, PDB-8xra: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.31 Å 38601 8xrb EMDB-38601, PDB-8xrb: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.49 Å 38602 8xrc EMDB-38602, PDB-8xrc: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.5 Å 38603 8xrd EMDB-38603, PDB-8xrd: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus 手法: EM (単粒子) / 解像度: 2.87 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-SIA: N-acetyl-alpha-neuraminic acid / N-アセチル-α-ノイラミン酸
由来	influenza a virus (strain a/korea/426/1968 h2n2) (A型インフルエンザウイルス) influenza a virus (A型インフルエンザウイルス)
キーワード	VIRAL PROTEIN / H2N2 / influenza virus / receptor / replication / transmission / mice / guinea pig / ferret / mutation / public health risk / VIRUS