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| Title | Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 68, Page 2466-2482, Year 2025 |
| Publish date | Sep 5, 2024 (structure data deposition date) |
 Authors | Filipski, K.J. / Martinez-Alsina, L.A. / Reese, M.R. / Evrard, E. / Buzon, L.M. / Cameron, K.O. / Zhang, Y. / Coffman, K.J. / Bradow, J. / Kormos, B.L. ...Filipski, K.J. / Martinez-Alsina, L.A. / Reese, M.R. / Evrard, E. / Buzon, L.M. / Cameron, K.O. / Zhang, Y. / Coffman, K.J. / Bradow, J. / Kormos, B.L. / Liu, S. / Knafels, J.D. / Sahasrabudhe, P.V. / Chen, J. / Kalgutkar, A.S. / Bessire, A.J. / Orozco, C.C. / Balesano, A. / Cerny, M.A. / Bollinger, E. / Reyes, A.R. / Laforest, B. / Rosado, A. / Williams, G. / Marshall, M. / Tam Neale, K. / Chen, X. / Hirenallur-Shanthappa, D. / Stansfield, J.C. / Groarke, J. / Qiu, R. / Karas, S. / Roth Flach, R.J. / Esler, W.P. |
 External links | J. Med. Chem. / PubMed:39560668 |
| Methods | X-ray diffraction |
| Resolution | 2.155 Å |
| Structure data |  PDB-9di9: |
| Chemicals |  ChemComp-ADP:  ChemComp-MG:  ChemComp-K:  PDB-1a40:  ChemComp-PO4:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / branch chain ketoacid dehydrogenase / branch chain ketoacid dehydrogenase kinase / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)