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TitleStructural insights into the inhibition mechanism of glucosidase inhibitors toward kojibiose hydrolase belonging to glycoside hydrolase family 65.
Journal, issue, pagesBiosci. Biotechnol. Biochem., Vol. 89, Page 72-79, Year 2024
Publish dateMar 29, 2024 (structure data deposition date)
AuthorsNakamura, S. / Miyazaki, T.
External linksBiosci. Biotechnol. Biochem. / PubMed:39533825
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-8yvr:
Crystal structure of GH65 alpha-1,2-glucosidase from Flavobacterium johnsoniae in complex with 1-deoxynojirimycin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8yvs:
Crystal structure of GH65 alpha-1,2-glucosidase from Flavobacterium johnsoniae in complex with castanospermine
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-NOJ:
1-DEOXYNOJIRIMYCIN / inhibitor*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CTS:
CASTANOSPERMINE / antivirus, inhibitor, alkaloid*YM

Source
  • flavobacterium johnsoniae uw101 (bacteria)
KeywordsHYDROLASE / glycoside hydrolase / GH65 / kojibiose / (alpha/alpha)6-barrel / inhibitor / glucosidase / dextran

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