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TitleCovalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 20214-20223, Year 2024
Publish dateJul 9, 2024 (structure data deposition date)
AuthorsAlboreggia, G. / Udompholkul, P. / Atienza, E.L. / Muzzarelli, K. / Assar, Z. / Pellecchia, M.
External linksJ. Med. Chem. / PubMed:39532346
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-9ckn:
Histidine-covalent alpha-helical peptide (compound 6) targeting hMcl-1
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / Histidine-covalent stapled alpha-helical peptides

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