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TitleStructure-based design of glycoprotein subunit vaccines for mumps.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2404053121-e2404053121, Year 2024
Publish dateSep 26, 2024 (structure data deposition date)
AuthorsLoomis, R.J. / Lai, Y.T. / Sowers, S.B. / Fisher, B. / Derrien-Colemyn, A. / Ambrozak, D.R. / Tsybovsky, Y. / Crooke, S.N. / Latner, D.R. / Kong, W.P. ...Loomis, R.J. / Lai, Y.T. / Sowers, S.B. / Fisher, B. / Derrien-Colemyn, A. / Ambrozak, D.R. / Tsybovsky, Y. / Crooke, S.N. / Latner, D.R. / Kong, W.P. / Ruckwardt, T.J. / Plotkin, S.A. / Kwong, P.D. / Mascola, J.R. / Graham, B.S. / Hickman, C.J. / Stewart-Jones, G.B.E.
External linksProc. Natl. Acad. Sci. USA / PubMed:39527740
MethodsX-ray diffraction
Resolution2.16 Å
Structure data

PDB-9drq:
Mumps virus fusion glycoprotein F stabilized in prefusion conformation
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • mumps orthorubulavirus
KeywordsVIRAL PROTEIN / Mumps virus / fusion protein / prefusion conformation / vaccine

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