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TitleBroadening alloselectivity of T cell receptors by structure guided engineering.
Journal, issue, pagesSci Rep, Vol. 14, Page 26851-26851, Year 2024
Publish dateFeb 9, 2024 (structure data deposition date)
AuthorsKaruppiah, V. / Sangani, D. / Whaley, L. / Pengelly, R. / Uluocak, P. / Carreira, R.J. / Hock, M. / Cristina, P.D. / Bartasun, P. / Dobrinic, P. ...Karuppiah, V. / Sangani, D. / Whaley, L. / Pengelly, R. / Uluocak, P. / Carreira, R.J. / Hock, M. / Cristina, P.D. / Bartasun, P. / Dobrinic, P. / Smith, N. / Barnbrook, K. / Robinson, R.A. / Harper, S.
External linksSci Rep / PubMed:39500929
MethodsX-ray diffraction
Resolution1.81 - 2.49 Å
Structure data

PDB-8rym:
Structure of S2 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-8ryn:
Structure of S2 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-8ryo:
Structure of S2-198 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-8ryp:
Structure of S8 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-8ryq:
Structure of S8-9F3 TCR in complex with HLA-A*11:01 bound to ELFSYLIEK peptide
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-TOE:
2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TCR / HLA

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