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TitleStructural Plasticity within 3-Hydroxy-3-Methylglutaryl Synthases Catalyzing the First Step of beta-Branching in Polyketide Biosynthesis Underpins a Dynamic Mechanism of Substrate Accommodation.
Journal, issue, pagesJacs Au, Vol. 4, Page 3833-3847, Year 2024
Publish dateMar 5, 2024 (structure data deposition date)
AuthorsCollin, S. / Weissman, K.J. / Gruez, A.
External linksJacs Au / PubMed:39483223
MethodsX-ray diffraction
Resolution1.99 Å
Structure data

PDB-8s81:
VirC mutant C114A-Q334A-R335A-R338A
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • streptomyces virginiae (bacteria)
KeywordsTRANSFERASE / 3-hydroxy-3-methylglutaryl-CoA synthase / conformational flexibility / substrate specificity

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