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TitleThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 8887, Year 2024
Publish dateOct 15, 2024
AuthorsZhuo Han / Rui Wang / Pengliang Chi / Zihan Zhang / Ling Min / Haizhan Jiao / Guojin Ou / Dan Zhou / Dandan Qin / Chengpeng Xu / Zheng Gao / Qianqian Qi / Jialu Li / Yuechao Lu / Xiang Wang / Jing Chen / Xingjiang Yu / Hongli Hu / Lei Li / Dong Deng /
PubMed AbstractThe subcortical maternal complex (SCMC) is essential for safeguarding female fertility in mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but the underlying mechanism ...The subcortical maternal complex (SCMC) is essential for safeguarding female fertility in mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but the underlying mechanism remains unclear. Here, we report that 14-3-3, a multifunctional protein, is a component of the SCMC. By resolving the structure of the 14-3-3-containing SCMC, we discover that phosphorylation of TLE6 contributes to the recruitment of 14-3-3. Mechanistically, during maternal-to-embryo transition, the SCMC stabilizes 14-3-3 protein and contributes to the proper control of CDC25B, thus ensuring the activation of the maturation-promoting factor and mitotic entry in mouse zygotes. Notably, the SCMC establishes a conserved molecular link with 14-3-3 and CDC25B in human oocytes/embryos. This study discloses the molecular mechanism through which the SCMC regulates the cell cycle in early embryos and elucidates the function of the SCMC in mammalian early embryogenesis.
External linksNat Commun / PubMed:39406751 / PubMed Central
MethodsEM (single particle)
Resolution3.0 Å
Structure data

38369

8xi3

EMDB-38369, PDB-8xi3:
Structure of mouse SCMC-14-3-3gama complex
Method: EM (single particle) / Resolution: 3.0 Å

Source
  • mus musculus (house mouse)
KeywordsCYTOSOLIC PROTEIN / Complex / Oocyte subcortical / phosphorylation / 14-3-3

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