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TitleCharacterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration.
Journal, issue, pagesMabs, Vol. 16, Page 2415060-2415060, Year 2024
Publish dateAug 14, 2023 (structure data deposition date)
AuthorsTamburini, P. / Pedersen, D.V. / Devore, D. / Cone, J. / Patel, R. / Hunter, T. / Sun, F. / Andersen, G.R. / Hunter, J.
External linksMabs / PubMed:39397258
MethodsX-ray diffraction
Resolution1.225 - 1.9 Å
Structure data

PDB-8q6r:
Structure of complement FP in complex with the TPP-3077 VHH
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8q78:
Structure of the FP specific VHH TPP-3077
Method: X-RAY DIFFRACTION / Resolution: 1.225 Å

Chemicals

ChemComp-GCH:
GLYCOCHOLIC ACID

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • lama glama (llama)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complement / antibody / properdin / alternative pathway

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