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Structure paper

TitleRecurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions.
Journal, issue, pagesBiochemistry, Vol. 63, Page 2718-2722, Year 2024
Publish dateJun 10, 2024 (structure data deposition date)
AuthorsMaji, D. / Jenkins, J.L. / Boutz, P.L. / Kielkopf, C.L.
External linksBiochemistry / PubMed:39388459
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-9c7a:
Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-9c7b:
Crystal structure of R150H neurodevelopmental disease-associated U2AF2 variant
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsRNA BINDING PROTEIN/RNA/DNA / PROTEIN-RNA COMPLEX / RNA SPLICING FACTOR / RNA RECOGNITION MOTIF / POLYPYRIMIDINE TRACT / RNA BINDING PROTEIN-RNA COMPLEX / RNA BINDING PROTEIN-SPLICING complex / RNA BINDING PROTEIN / RNA BINDING PROTEIN-RNA-DNA complex

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