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TitleDiscovery of CZL-046 with an ( S )-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 18606-18628, Year 2024
Publish dateAug 16, 2024 (structure data deposition date)
AuthorsChen, Z. / Yang, H. / Zhang, Y. / Lyu, X. / Shi, Q. / Zhang, C. / Wang, X. / Wang, Z. / Deng, Y. / Wang, Y. ...Chen, Z. / Yang, H. / Zhang, Y. / Lyu, X. / Shi, Q. / Zhang, C. / Wang, X. / Wang, Z. / Deng, Y. / Wang, Y. / Huang, Y. / Xu, Y. / Huang, X. / Li, Y.
External linksJ. Med. Chem. / PubMed:39356741
MethodsX-ray diffraction
Resolution2.67 Å
Structure data

PDB-9j6o:
Crystal Structure of bromodomain of human CBP in complex with the inhibitor CZL-046
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

Chemicals

PDB-1l3s:
Crystal Structure of Bacillus DNA Polymerase I Fragment complexed to 9 base pairs of duplex DNA.

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / bromodomain / CBP / inhibitor

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