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Structure paper

TitleProtein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.
Journal, issue, pagesNucleic Acids Res., Vol. 52, Page 12701-12711, Year 2024
Publish dateMar 4, 2024 (structure data deposition date)
AuthorsNaineni, S.K. / Bhatt, G. / Jiramongkolsiri, E. / Robert, F. / Cencic, R. / Huang, S. / Nagar, B. / Pelletier, J.
External linksNucleic Acids Res. / PubMed:39351865
MethodsX-ray diffraction
Resolution1.91 Å
Structure data

PDB-9avr:
Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-IOD:
IODIDE ION

PDB-1ag8:
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / Eukaryotic initiation factor 4A-1 / silvestrol inhibitor / anti-cancer / RNA binding / drug

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