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TitleNVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations.
Journal, issue, pagesCancer Discov, Vol. 14, Page 2367-2386, Year 2024
Publish dateJul 31, 2024 (structure data deposition date)
AuthorsLin, J.J. / Horan, J.C. / Tangpeerachaikul, A. / Swalduz, A. / Valdivia, A. / Johnson, M.L. / Besse, B. / Camidge, D.R. / Fujino, T. / Yoda, S. ...Lin, J.J. / Horan, J.C. / Tangpeerachaikul, A. / Swalduz, A. / Valdivia, A. / Johnson, M.L. / Besse, B. / Camidge, D.R. / Fujino, T. / Yoda, S. / Nguyen-Phuong, L. / Mizuta, H. / Bigot, L. / Nobre, C. / Lee, J.B. / Yu, M.R. / Mente, S. / Sun, Y. / Kohl, N.E. / Porter, J.R. / Shair, M.D. / Zhu, V.W. / Felip, E. / Cho, B.C. / Friboulet, L. / Hata, A.N. / Pelish, H.E. / Drilon, A.
External linksCancer Discov / PubMed:39269178
MethodsX-ray diffraction
Resolution1.58 Å
Structure data

PDB-9gbe:
Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

PDB-1ij8:
CRYSTAL STRUCTURE OF LITE AVIDIN-BNI COMPLEX

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / ALK / Tyrosine Kinase Inhibitor / Resistance / NVL-655

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