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TitleDiscovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules.
Journal, issue, pagesMol. Cancer Ther., Vol. 23, Page 1689-1702, Year 2024
Publish dateJul 20, 2023 (structure data deposition date)
AuthorsGollner, A. / Rudolph, D. / Weyer-Czernilofsky, U. / Baumgartinger, R. / Jung, P. / Weinstabl, H. / Ramharter, J. / Grempler, R. / Quant, J. / Rinnenthal, J. ...Gollner, A. / Rudolph, D. / Weyer-Czernilofsky, U. / Baumgartinger, R. / Jung, P. / Weinstabl, H. / Ramharter, J. / Grempler, R. / Quant, J. / Rinnenthal, J. / Perez Pitarch, A. / Golubovic, B. / Gerlach, D. / Bader, G. / Wetzel, K. / Otto, S. / Mandl, C. / Boehmelt, G. / McConnell, D.B. / Kraut, N. / Sini, P.
External linksMol. Cancer Ther. / PubMed:39259562
MethodsX-ray diffraction
Resolution1.461 Å
Structure data

PDB-8pwc:
Crystal structure of MDM2 with Brigimadlin
Method: X-RAY DIFFRACTION / Resolution: 1.461 Å

Chemicals


ChemComp, No image

ChemComp-G7I:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / Inhibitor / Complex

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