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Structure paper

TitleTargeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Journal, issue, pagesCell, Vol. 187, Page 6379-, Year 2024
Publish dateJul 27, 2023 (structure data deposition date)
AuthorsMorstein, J. / Bowcut, V. / Fernando, M. / Yang, Y. / Zhu, L. / Jenkins, M.L. / Evans, J.T. / Guiley, K.Z. / Peacock, D.M. / Krahnke, S. ...Morstein, J. / Bowcut, V. / Fernando, M. / Yang, Y. / Zhu, L. / Jenkins, M.L. / Evans, J.T. / Guiley, K.Z. / Peacock, D.M. / Krahnke, S. / Lin, Z. / Taran, K.A. / Huang, B.J. / Stephen, A.G. / Burke, J.E. / Lightstone, F.C. / Shokat, K.M.
External linksCell / PubMed:39255801
MethodsX-ray diffraction
Resolution1.70003947485 Å
Structure data

PDB-8tlr:
Crystal Structure of human HRAS G12C covalently bound to AMG 510
Method: X-RAY DIFFRACTION / Resolution: 1.70003947485 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MOV:
AMG 510 (bound form)

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / HRAS / H-Ras / sotorasib / Ras

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