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TitleSynthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.
Journal, issue, pagesNucleic Acids Res., Vol. 52, Page 10754-10774, Year 2024
Publish dateMar 11, 2024 (structure data deposition date)
AuthorsNomura, K. / An, S. / Kobayashi, Y. / Kondo, J. / Shi, T. / Murase, H. / Nakamoto, K. / Kimura, Y. / Abe, N. / Ui-Tei, K. / Abe, H.
External linksNucleic Acids Res. / PubMed:39231537
MethodsX-ray diffraction
Resolution1.3 - 1.4 Å
Structure data

PDB-8yno:
RNA duplex containing Formamide
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-8ynp:
RNA duplex containing Methylformamide
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-SPM:
SPERMINE

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / Formamide / Methylformamide

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