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Structure paper

TitleAdditional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
Journal, issue, pagesElife, Vol. 13, Year 2024
Publish dateFeb 28, 2023 (structure data deposition date)
AuthorsLenka, D.R. / Dahe, S.V. / Antico, O. / Sahoo, P. / Prescott, A.R. / Muqit, M.M.K. / Kumar, A.
External linksElife / PubMed:39221915
MethodsX-ray diffraction
Resolution1.92 - 3.3 Å
Structure data

PDB-8ik6:
pUbl depleted Parkin complex with pUbiquitin
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-8ikm:
Trans complex of phospho parkin
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-8ikt:
Ternary trans-complex of phospho-parkin with cis ACT and pUb
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8ikv:
pUbl depleted phospho-Parkin(K211N,R163D) in complex with pUb
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-8jwv:
Untethered R0RBR
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-3CN:
3-AMINOPROPANE

ChemComp-BA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 Ligase

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