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TitleStructural basis for mouse LAG3 interactions with the MHC class II molecule I-A b.
Journal, issue, pagesNat Commun, Vol. 15, Page 7513-7513, Year 2024
Publish dateAug 2, 2024 (structure data deposition date)
AuthorsMing, Q. / Antfolk, D. / Price, D.A. / Manturova, A. / Medina, E. / Singh, S. / Mason, C. / Tran, T.H. / Smalley, K.S.M. / Leung, D.W. / Luca, V.C.
External linksNat Commun / PubMed:39209860
MethodsX-ray diffraction
Resolution3.84 - 4.66 Å
Structure data

PDB-9cyl:
Structure of LAG3 loop1 deletion bound to the MHC class II molecule I-A(b)
Method: X-RAY DIFFRACTION / Resolution: 4.66 Å

PDB-9cym:
Structure of LAG3 bound to the MHC class II molecule I-A(b)
Method: X-RAY DIFFRACTION / Resolution: 3.84 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / LAG3 / Immune checkpoint / T cell / complex / MHCII / immune therapy / MHC class II

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