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TitleStructural insights into ternary immunocomplex formation and cross-reactivity: binding of an anti-immunocomplex FabB12 to Fab220-testosterone complex.
Journal, issue, pagesFebs J., Vol. 291, Page 4744-4756, Year 2024
Publish dateJan 29, 2024 (structure data deposition date)
AuthorsEronen, V. / Takkinen, K. / Torni, A. / Peng, K. / Janis, J. / Parkkinen, T. / Hakulinen, N. / Rouvinen, J.
External linksFebs J. / PubMed:39206623
MethodsX-ray diffraction
Resolution1.99 - 2.7 Å
Structure data

PDB-8rtw:
Crystal Structure of the Anti-testosterone Fab in Complex with Testosterone
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-8rtx:
Crystal Structure of an Anti-idiotype Fab Fragment
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-TES:
TESTOSTERONE

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Fab / Testosterone / idiotype

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