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Structure paper

TitleA bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders.
Journal, issue, pagesNat Cardiovasc Res, Vol. 3, Page 166-185, Year 2024
Publish dateFeb 7, 2023 (structure data deposition date)
AuthorsGandhi, P.S. / Zivkovic, M. / Ostergaard, H. / Bonde, A.C. / Elm, T. / Lovgreen, M.N. / Schluckebier, G. / Johansson, E. / Olsen, O.H. / Olsen, E.H.N. ...Gandhi, P.S. / Zivkovic, M. / Ostergaard, H. / Bonde, A.C. / Elm, T. / Lovgreen, M.N. / Schluckebier, G. / Johansson, E. / Olsen, O.H. / Olsen, E.H.N. / de Bus, I.A. / Bloem, K. / Alskar, O. / Rea, C.J. / Bjorn, S.E. / Schutgens, R.E. / Sorensen, B. / Urbanus, R.T. / Faber, J.H.
External linksNat Cardiovasc Res / PubMed:39196196
MethodsX-ray diffraction
Resolution1.49 - 3.4 Å
Structure data

PDB-8che:
TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-8cn9:
Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-CS:
Unknown entry

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / TLT-1 / Fab / Bispecific Antibody / HMB-001 / Factor VII

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