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Structure paper

TitleAficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Journal, issue, pagesNat Cardiovasc Res, Vol. 3, Page 1003-1016, Year 2024
Publish dateMay 1, 2024 (structure data deposition date)
AuthorsHartman, J.J. / Hwee, D.T. / Robert-Paganin, J. / Chuang, C. / Chin, E.R. / Edell, S. / Lee, K.H. / Madhvani, R. / Paliwal, P. / Pernier, J. ...Hartman, J.J. / Hwee, D.T. / Robert-Paganin, J. / Chuang, C. / Chin, E.R. / Edell, S. / Lee, K.H. / Madhvani, R. / Paliwal, P. / Pernier, J. / Sarkar, S.S. / Schaletzky, J. / Schauer, K. / Taheri, K.D. / Wang, J. / Wehri, E. / Wu, Y. / Houdusse, A. / Morgan, B.P. / Malik, F.I.
External linksNat Cardiovasc Res / PubMed:39196032
MethodsX-ray diffraction
Resolution2.33 Å
Structure data

PDB-9f6c:
Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry


ChemComp, No image

ChemComp-6I6:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-VO4:
VANADATE ION

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
KeywordsMOTOR PROTEIN / cardiac myosin / modulator / cardiomyopathy / force production

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