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Structure paper

TitleBRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models.
Journal, issue, pagesNat Cancer, Vol. 5, Page 1479-1493, Year 2024
Publish dateJun 15, 2023 (structure data deposition date)
AuthorsRauh, U. / Wei, G. / Serrano-Wu, M. / Kosmidis, G. / Kaulfuss, S. / Siegel, F. / Thede, K. / McFarland, J. / Lemke, C.T. / Werbeck, N. ...Rauh, U. / Wei, G. / Serrano-Wu, M. / Kosmidis, G. / Kaulfuss, S. / Siegel, F. / Thede, K. / McFarland, J. / Lemke, C.T. / Werbeck, N. / Nowak-Reppel, K. / Pilari, S. / Menz, S. / Ocker, M. / Zhang, W. / Davis, K. / Poncet-Montange, G. / Roth, J. / Daniels, D. / Kaushik, V.K. / Hubbard, B. / Ziegelbauer, K. / Golub, T.R.
External linksNat Cancer / PubMed:39179926
MethodsX-ray diffraction
Resolution1.56 Å
Structure data

PDB-8t6f:
Crystal structure of human MBP-Myeloid cell leukemia 1 (Mcl-1) in complex with BRD810 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

Chemicals

ChemComp-MG:
Unknown entry


ChemComp, No image

ChemComp-YI7:
Unknown entry

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • escherichia coli k-12 (bacteria)
  • homo sapiens (human)
KeywordsAPOPTOSIS / Inhibitor / MCL1 / MBP-fusion / BRD810

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