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TitleNovel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Journal, issue, pagesSci Rep, Vol. 14, Page 19656-19656, Year 2024
Publish dateNov 10, 2022 (structure data deposition date)
AuthorsJungholm, O. / Trkulja, C. / Moche, M. / Srinivasa, S.P. / Christakopoulou, M.N. / Davidson, M. / Reymer, A. / Jardemark, K. / Fogaca, R.L. / Ashok, A. ...Jungholm, O. / Trkulja, C. / Moche, M. / Srinivasa, S.P. / Christakopoulou, M.N. / Davidson, M. / Reymer, A. / Jardemark, K. / Fogaca, R.L. / Ashok, A. / Jeffries, G. / Ampah-Korsah, H. / Strandback, E. / Andrell, J. / Nyman, T. / Nouairia, G. / Orwar, O.
External linksSci Rep / PubMed:39179604
MethodsX-ray diffraction
Resolution1.4 - 2 Å
Structure data

PDB-8blr:
G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8cpr:
G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / KRAS / colorectal cancer / RAS signalling / cancer stem cells / RAS-driven metastasis / KRAS structure / KRAS mutations

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