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TitleStabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor.
Journal, issue, pagesProtein Sci., Vol. 33, Page e5151-e5151, Year 2024
Publish dateMay 10, 2023 (structure data deposition date)
AuthorsMpakali, A. / Georgaki, G. / Buson, A. / Findlay, A.D. / Foot, J.S. / Mauvais, F.X. / van Endert, P. / Giastas, P. / Hamprecht, D.W. / Stratikos, E.
External linksProtein Sci. / PubMed:39167040
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-8p0i:
Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose


ChemComp, No image

ChemComp-WC3:
Unknown entry

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE / insulin regulated aminopeptidase / irap / hsplap / antigen presentation / inhibitor

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