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Structure paper

TitleGcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2409628121-e2409628121, Year 2024
Publish dateJun 14, 2024 (structure data deposition date)
AuthorsBou-Nader, C. / Gaikwad, S. / Bahmanjah, S. / Zhang, F. / Hinnebusch, A.G. / Zhang, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:39163341
MethodsX-ray diffraction
Resolution2 - 2.69 Å
Structure data

PDB-9c9q:
Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9c9r:
Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain, F1090C/G1326S variant
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

PDB-9cbs:
Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain, catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • thermochaetoides thermophila (fungus)
KeywordsTRANSFERASE / GCN2 Integrative stress response / TRANSLATION / stress response / gcn2 / tRNA-binding / regulatory

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